Messenger molecule bind with specific target proteins, to cause some effect on the target cell.
Target proteins are useful biomolecules that biologically active substances interact with and regulate.
They are utilized during the transduction, transformation, and conjugation processes.
An developing therapeutic approach known as targeted protein degradation (TPD) has the potential to address disease-causing proteins that have hitherto been very difficult to target with traditional small molecules.
Proteases, kinases, G protein-coupled receptors (GPCRs), and nuclear hormone receptors are currently the protein targets for which effective medicines have been produced.
Typically bioactive small compounds are coupled onto solid supports and then used to separate target proteins from the entire proteome for target protein identification.
High binding affinity between bioactive small molecules and their intended protein targets is necessary for this method.
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